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(4DG is a fiber configuration that includes deep grooves or channels along the longitudinal axis of the fiber, providing for capillary movement of fluids and a large surface area relative to bulk as compared to columnar fibers)

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The precise mechanism by which testosterone decreases as serum cotinine concentration rises beyond a certain threshold remains unclear

As no information about the most likely function for dosage distribution is available, a uniform probability distribution was entered into the calculation in this case (Supplementary Table S1)